Oxytocin & Cholesterol
نویسنده
چکیده
E-mail:[email protected] © All Natural Advantage Helping children achieve their full potential Oxytocin is a hormone that has long been associated with uterine contraction during childbirth and milk let-down during nursing. While this description is basically correct, it does not explain why males have oxytocin, why increased oxytocin is often not detected during labour, or how oxytocin affects memory, stress responses and renal function.
منابع مشابه
Molecular modelling study of the role of cholesterol in the stimulation of the oxytocin receptor.
Cholesterol, an integral component of membranes in Eucaryota, is a modifier of membrane properties. In vivo studies have demonstrated that cholesterol can also modulate activities of some G protein-coupled receptors (GPCRs), which are integral membrane proteins. This can result either from an effect of cholesterol on the membrane fluidity or from specific interactions of the membrane cholestero...
متن کاملEffects of cholesterol manipulation on the signaling of the human oxytocin receptor.
We have recently shown that oxytocin inhibits cell growth when the vast majority of oxytocin receptors (OTRs) are excluded from detergent-resistant membranes (DRMs; the biochemical counterpart of lipid rafts), but has a strong mitogenic effect when the receptors are targeted to these plasma membrane domains upon fusion with caveolin-2, a resident raft protein. The aim of this study was to inves...
متن کاملCALL FOR PAPERS Neurohypophyseal Hormones: From Genomics and Physiology to Disease Effects of cholesterol manipulation on the signaling of the human oxytocin receptor
Reversi, Alessandra, Valeria Rimoldi, Silvia Brambillasca, and Bice Chini. Effects of cholesterol manipulation on the signaling of the human oxytocin receptor. Am J Physiol Regul Integr Comp Physiol 291: R861–R869, 2006. First published June 1, 2006; doi:10.1152/ajpregu.00333.2006.—We have recently shown that oxytocin inhibits cell growth when the vast majority of oxytocin receptors (OTRs) are ...
متن کاملMembrane cholesterol extraction decreases Na+ transport in A6 renal epithelia.
In this study, we have investigated the dependence of Na+ transport regulation on membrane cholesterol content in A6 renal epithelia. We continuously monitored short-circuit current (Isc), transepithelial conductance (GT), and transepithelial capacitance (CT) to evaluate the effects of cholesterol extraction from the apical and basolateral membranes in steady-state conditions and during activat...
متن کاملOxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus.
The uterus is an organ where lipid distribution plays a critical role for its function. Here we show that nuclear receptor for oxysterols LXRbeta prevents accumulation of cholesteryl esters in mouse myometrium by controlling expression of genes involved in cholesterol efflux and storage (abca1 and abcg1). Upon treatment with an LXR agonist that mimics activation by oxysterols, expression of the...
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تاریخ انتشار 2014